The Poison Centipede build is an excellent end-game build for the Spiritborn class in Diablo 4: Vessel of Hatred, using the unique synergy between Thorns, poison, and crowd control while minimizing reliance on the class’s primary resource. This build uses specific unique items and legendary aspects to transform core skills into basic skills, allowing for constant casting without resource use. It is very good at creating a powerful force through poison and thorns, applying both to enemies through skills and weapons.