Weapon Runes are equipped to your weapons to activate special abilities in No Rest for the Wicked, allowing you to further customize your build. This guide covers the best Runes in No Rest for the Wicked that offer the most benefits against the game’s most challenging enemies.No Rest for the Wicked: Which runes are the best?Early access for No Rest for the Wicked has provided the player base with tons of runes to customize their build. Not all of them are created equal, though. Here are our picks for the best runes ThornsScreenshot: PC InvasionThe Thorns rune can come in handy during a challenging fight, as it can be the last inch of damage you need to defeat the enemy. When applied, Thorns inflict damage every time the enemy lands a hit on you. So, if you make a mistake and take damage, the enemy will also get punished for it.How to get: Can be purchased from Eleanor after upgrading her shop to tier 3.ScreamScreenshot: PC InvasionScream is a…